Hexb | hexosaminidase B

GeneMGI:96074

Physiological systems

15 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Hematopoietic system Behavior/neurological

11 No significant impact

9 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

4Associated diseases

Expression examined in:46Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased monocyte cell number	2 supporting datasets	Hexb^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.07x10^-5
tremors	1 supporting dataset	Hexb^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.7x10^-6
increased circulating aspartate transaminase level	1 supporting dataset	Hexb^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.13x10^-11
increased circulating iron level	1 supporting dataset	Hexb^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.88x10^-6
abnormal locomotor behavior	1 supporting dataset	Hexb^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.47x10^-5
thrombocytosis	1 supporting dataset	Hexb^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.29x10^-5
decreased exploration in new environment	1 supporting dataset	Hexb^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.62x10^-5
abnormal gait	1 supporting dataset	Hexb^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.02x10^-11
decreased circulating fructosamine level	1 supporting dataset	Hexb^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.13x10^-6
increased circulating alkaline phosphatase level	1 supporting dataset	Hexb^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.86x10^-22

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Hexb.

Associated images

Loading...

Histopathology

There is no histopathology data found for Hexb.

IMPC related publications

Loading...

External links

No external links available for Hexb.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Hexb^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Hexb^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Hexb^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

My Genes