Gria2 | glutamate receptor, ionotropic, AMPA2 (alpha 2)

GeneMGI:95809Synonyms: Glur-2, GluR2, +3 more

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Behavior/neurological Mortality/aging Cardiovascular system

13 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Gria2^em1(IMPC)H	homozygote	Early adult	N/A ^*
decreased grip strength	1 supporting dataset	Gria2^em1(IMPC)H	heterozygote	Early adult	3.22x10^-6
increased circulating alanine transaminase level	1 supporting dataset	Gria2^em1(IMPC)H	heterozygote	Early adult	4.76x10^-9
prolonged QRS complex duration	1 supporting dataset	Gria2^em1(IMPC)H	heterozygote	Early adult	2.29x10^-10

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gria2.

Associated images

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Histopathology

There is no histopathology data found for Gria2.

IMPC related publications

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External links

No external links available for Gria2.

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*Gria2^em1(IMPC)H*	Exon Deletion	‌	mouse
*Gria2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Gria2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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