Grb2 | growth factor receptor bound protein 2

Physiological systems

20 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Behavior/neurological Mortality/aging

18 No significant impact

4 Not tested

Gene metrics:2Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues

Phenotypes

abnormal behavior1 supporting datasetGrb2tm1a(EUCOMM)WtsiheterozygoteEarly adult7.64x10-5 
preweaning lethality, complete penetrance1 supporting datasetGrb2tm1a(EUCOMM)WtsihomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Grb2tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Grb2tm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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