Got2 | glutamatic-oxaloacetic transaminase 2, mitochondrial

GeneMGI:95792Synonyms: mitochondrial aspartate aminotransferase, FABP-pm, +3 more

Physiological systems

22 / 24 physiological systems tested

11 Significantly impacted by the knock-out

 Immune system Embryo Growth/size/body region Digestive/alimentary Nervous system Vision/eye Hematopoietic system Cardiovascular system Mortality/aging Craniofacial Renal/urinary system

11 No significant impact

2 Not tested

Gene metrics:21Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

cataract1 supporting datasetGot2em1(IMPC)MbpheterozygoteEarly adult9.23x10-5 
embryonic growth retardation1 supporting datasetGot2em1(IMPC)MbpheterozygoteE15.5N/A * 
abnormal heart morphology1 supporting datasetGot2em1(IMPC)MbphomozygoteE9.5N/A * 
abnormal forebrain development1 supporting datasetGot2em1(IMPC)MbphomozygoteE9.5N/A * 
abnormal blood vessel morphology1 supporting datasetGot2em1(IMPC)MbphomozygoteE9.5N/A * 
hemorrhage1 supporting datasetGot2em1(IMPC)MbphomozygoteE9.5N/A * 
abnormal vitelline vasculature morphology1 supporting datasetGot2em1(IMPC)MbphomozygoteE9.5N/A * 
abnormal midbrain development1 supporting datasetGot2em1(IMPC)MbphomozygoteE9.5N/A * 
prenatal lethality prior to heart atrial septation1 supporting datasetGot2em1(IMPC)MbphomozygoteE15.5N/A * 
small spleen2 supporting datasetsGot2em1(IMPC)MbpheterozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Got2em1(IMPC)MbpExon Deletionmouse
Got2tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Got2tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Got2tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell
Got2tm2a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Got2tm2e(EUCOMM)HmguTargeted, non-conditional alleleES Cell
Got2tm3a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse

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