Gnb1 | guanine nucleotide binding protein (G protein), beta 1
GeneMGI:95781
Physiological systems
21 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Growth/size/body region Vision/eye Behavior/neurological Skeleton Mortality/aging Craniofacial
15 No significant impact
3 Not tested
Data collections
Gene metrics:8Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
facial cleft | 1 supporting dataset | Gnb1em1(IMPC)Bay | homozygote | E18.5 | N/A * | ||
preweaning lethality, complete penetrance | 3 supporting datasets | Gnb1em1(IMPC)Bay | homozygote | Early adult | N/A * | ||
decreased anxiety-related response | 1 supporting dataset | Gnb1em1(IMPC)Bay | heterozygote | Early adult | 3.32x10-5 | ||
decreased total retina thickness | 2 supporting datasets | Gnb1em1(IMPC)Bay | heterozygote | Early adult | 3.55x10-6 | ||
increased bone mineral content | 2 supporting datasets | Gnb1em1(IMPC)Bay | heterozygote | Early adult | 9.93x10-6 | ||
hyperactivity | 7 supporting datasets | Gnb1em1(IMPC)Bay | heterozygote | Early adult | 6.28x10-12 | ||
increased vertical activity | 1 supporting dataset | Gnb1em1(IMPC)Bay | heterozygote | Early adult | 4.08x10-7 | ||
abnormal retina outer nuclear layer morphology | 1 supporting dataset | Gnb1em1(IMPC)Bay | heterozygote | Early adult | 9.93x10-7 |
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External links
No external links available for Gnb1.
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Gnb1em1(IMPC)Bay | Exon Deletion | | mouse |
Gnb1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |