Gnb1 | guanine nucleotide binding protein (G protein), beta 1

Physiological systems

21 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Growth/size/body region Vision/eye Behavior/neurological Skeleton Mortality/aging Craniofacial

15 No significant impact

3 Not tested

Gene metrics:8Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

facial cleft1 supporting datasetGnb1em1(IMPC)BayhomozygoteE18.5N/A * 
preweaning lethality, complete penetrance3 supporting datasetsGnb1em1(IMPC)BayhomozygoteEarly adultN/A * 
decreased anxiety-related response1 supporting datasetGnb1em1(IMPC)BayheterozygoteEarly adult3.32x10-5 
decreased total retina thickness2 supporting datasetsGnb1em1(IMPC)BayheterozygoteEarly adult3.55x10-6 
increased bone mineral content2 supporting datasetsGnb1em1(IMPC)BayheterozygoteEarly adult9.93x10-6 
hyperactivity7 supporting datasetsGnb1em1(IMPC)BayheterozygoteEarly adult6.28x10-12 
increased vertical activity1 supporting datasetGnb1em1(IMPC)BayheterozygoteEarly adult4.08x10-7 
abnormal retina outer nuclear layer morphology1 supporting datasetGnb1em1(IMPC)BayheterozygoteEarly adult9.93x10-7 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Gnb1em1(IMPC)BayExon Deletionmouse
Gnb1tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
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