Gna13 | guanine nucleotide binding protein, alpha 13
Physiological systems
15 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Embryo Growth/size/body region Mortality/aging
12 No significant impact
9 Not tested
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:51Adult tissues
62Embryo tissues
| preweaning lethality, complete penetrance | 3 supporting datasets | Gna13tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Gna13tm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Gna13tm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * | ||
| abnormal visceral yolk sac morphology | 1 supporting dataset | Gna13tm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * |
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| adrenal gland | heterozygote | Wholemount images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | Wholemount images | n/a | 0% (0/394) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Wholemount images | 100% (2/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/1) | 7.75% (22/284) |
| cerebellum | heterozygote | Wholemount images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/491) |
Human diseases caused by Gna13 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Gna13.
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| Gna13tm1(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Gna13tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Gna13tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Gna13tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |