Gna11 | guanine nucleotide binding protein, alpha 11

GeneMGI:95766Synonyms: Dsk7

Physiological systems

22 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system Behavior/neurological Skeleton

18 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:15Significant phenotypes

9Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Allele:

Phy. System:



decreased hemoglobin content	1 supporting dataset	Gna11^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.26x10^-21
decreased circulating triglyceride level	1 supporting dataset	Gna11^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.34x10^-10
vertebral fusion	1 supporting dataset	Gna11^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	8.04x10^-7
increased circulating calcium level	1 supporting dataset	Gna11^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	7.37x10^-28
decreased hematocrit	1 supporting dataset	Gna11^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.07x10^-10
decreased erythrocyte cell number	1 supporting dataset	Gna11^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.24x10^-8
decreased circulating phosphate level	1 supporting dataset	Gna11^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.08x10^-5
increased startle reflex	3 supporting datasets	Gna11^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.6x10^-5
increased red blood cell distribution width	1 supporting dataset	Gna11^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.18x10^-7
increased circulating alanine transaminase level	1 supporting dataset	Gna11^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	7.31x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gna11.

Associated images

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Histopathology

There is no histopathology data found for Gna11.

IMPC related publications

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External links

No external links available for Gna11.

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*Gna11^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Gna11^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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