Glrb | glycine receptor, beta subunit

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Behavior/neurological Mortality/aging Cardiovascular system

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	2 supporting datasets	Glrb^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
increased circulating alanine transaminase level	1 supporting dataset	Glrb^em1(IMPC)Tcp	heterozygote	Early adult	1.21x10^-11
increased neutrophil cell number	1 supporting dataset	Glrb^em1(IMPC)Tcp	heterozygote	Early adult	2.39x10^-5
decreased circulating alkaline phosphatase level	1 supporting dataset	Glrb^em1(IMPC)Tcp	heterozygote	Early adult	8.79x10^-7
decreased freezing behavior	1 supporting dataset	Glrb^em1(IMPC)Tcp	heterozygote	Early adult	4.42x10^-6
increased heart weight	1 supporting dataset	Glrb^em1(IMPC)Tcp	heterozygote	Early adult	6.99x10^-6
increased spleen weight	1 supporting dataset	Glrb^em1(IMPC)Tcp	heterozygote	Early adult	6.15x10^-13
decreased circulating serum albumin level	1 supporting dataset	Glrb^em1(IMPC)Tcp	heterozygote	Early adult	6.99x10^-5
increased circulating aspartate transaminase level	1 supporting dataset	Glrb^em1(IMPC)Tcp	heterozygote	Early adult	1.41x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Glrb.

Associated images

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Histopathology

There is no histopathology data found for Glrb.

IMPC related publications

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External links

No external links available for Glrb.

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*Glrb^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Glrb^{tm42832(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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