Ghrh | growth hormone releasing hormone
Physiological systems
17 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Growth/size/body region Behavior/neurological Skeleton Cardiovascular system
11 No significant impact
7 Not tested
Data collections
Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| decreased lean body mass | 2 supporting datasets | Ghrhtm1b(EUCOMM)Wtsi | homozygote | Early adult | 7.48x10-37 | ||
| decreased heart weight | 2 supporting datasets | Ghrhtm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.05x10-20 | ||
| decreased grip strength | 2 supporting datasets | Ghrhtm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.97x10-8 | ||
| decreased fasting circulating glucose level | 1 supporting dataset | Ghrhtm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.1x10-5 | ||
| decreased body length | 1 supporting dataset | Ghrhtm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.42x10-70 | ||
| decreased bone mineral density | 1 supporting dataset | Ghrhtm1b(EUCOMM)Wtsi | homozygote | Early adult | 6.48x10-53 | ||
| increased total body fat amount | 2 supporting datasets | Ghrhtm1b(EUCOMM)Wtsi | homozygote | Early adult | 6.51x10-41 | ||
| decreased bone mineral content | 2 supporting datasets | Ghrhtm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.01x10-41 | ||
| impaired glucose tolerance | 2 supporting datasets | Ghrhtm1b(EUCOMM)Wtsi | homozygote | Early adult | 4.32x10-8 | ||
| abnormal bone structure | 1 supporting dataset | Ghrhtm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.61x10-41 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 50% (1/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
Human diseases caused by Ghrh mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ghrh.
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| Ghrhtm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ghrhtm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ghrhtm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |