Gba1 | glucosylceramidase beta 1

GeneMGI:95665Synonyms: glucocerebrosidase, GBA1, +4 more

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system Cardiovascular system Mortality/aging Craniofacial

12 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

13Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



increased mean platelet volume	1 supporting dataset	Gba1^em1(IMPC)H	heterozygote	Early adult	7.38x10^-6
preweaning lethality, complete penetrance	1 supporting dataset	Gba1^em1(IMPC)H	homozygote	Early adult	N/A ^*
abnormal craniofacial morphology	1 supporting dataset	Gba1^em1(IMPC)H	homozygote	E18.5	6.71x10^-6
increased circulating amylase level	1 supporting dataset	Gba1^em1(IMPC)H	heterozygote	Early adult	7.07x10^-8
prolonged QRS complex duration	1 supporting dataset	Gba1^em1(IMPC)H	heterozygote	Early adult	7.08x10^-12

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gba1.

Associated images

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Histopathology

There is no histopathology data found for Gba1.

IMPC related publications

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External links

No external links available for Gba1.

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*Gba1^em1(IMPC)H*	Exon Deletion	‌	mouse
*Gba1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Gba1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Gba1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Gba1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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