Gata2 | GATA binding protein 2

GeneMGI:95662Synonyms: Gata-2

Physiological systems

21 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Reproductive system Endocrine/exocrine gland Embryo Growth/size/body region Hearing/vestibular/ear Mortality/aging Renal/urinary system

14 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

7Associated diseases

Expression examined in:73Adult tissues

30Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



embryonic growth retardation	1 supporting dataset	Gata2^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
absent epididymis	1 supporting dataset	Gata2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	N/A ^*
enlarged epididymis	1 supporting dataset	Gata2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	N/A ^*
abnormal ovary morphology	1 supporting dataset	Gata2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	N/A ^*
abnormal epididymis morphology	1 supporting dataset	Gata2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	N/A ^*
abnormal auditory brainstem response	3 supporting datasets	Gata2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.22x10^-6
embryonic lethality prior to tooth bud stage	1 supporting dataset	Gata2^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
abnormal embryo size	1 supporting dataset	Gata2^{tm1b(KOMP)Wtsi}	heterozygote	E9.5	N/A ^*
embryonic growth retardation	1 supporting dataset	Gata2^{tm1b(KOMP)Wtsi}	heterozygote	E9.5	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Gata2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gata2.

Associated images

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Histopathology

There is no histopathology data found for Gata2.

IMPC related publications

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External links

No external links available for Gata2.

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*Gata2^{tm1(EGFP/cre/ERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Gata2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Gata2^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Gata2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Gata2^{tm209271(pL1L2_GT1_DelLacZ_bsd)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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