Gabrg2 | gamma-aminobutyric acid type A receptor, subunit gamma 2

GeneMGI:95623Synonyms: GABAA-R, Gabrg-2, +1 more

Physiological systems

22 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Reproductive system Endocrine/exocrine gland Integument Vision/eye Skeleton Mortality/aging Cardiovascular system

15 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

7Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	3 supporting datasets	Gabrg2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal retina morphology	1 supporting dataset	Gabrg2^em1(IMPC)Mbp	heterozygote	Early adult	1.69x10^-5
persistence of hyaloid vascular system	1 supporting dataset	Gabrg2^em1(IMPC)Mbp	heterozygote	Early adult	2.08x10^-9
decreased heart weight	2 supporting datasets	Gabrg2^em1(IMPC)Mbp	heterozygote	Early adult	8.97x10^-8
enlarged testis	1 supporting dataset	Gabrg2^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal ovary morphology	1 supporting dataset	Gabrg2^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
decreased bone mineral content	1 supporting dataset	Gabrg2^em1(IMPC)Mbp	heterozygote	Early adult	9.37x10^-5
abnormal testis morphology	1 supporting dataset	Gabrg2^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal skin morphology	1 supporting dataset	Gabrg2^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
decreased bone mineral density	1 supporting dataset	Gabrg2^em1(IMPC)Mbp	heterozygote	Early adult	1.87x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gabrg2.

Associated images

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Histopathology

There is no histopathology data found for Gabrg2.

IMPC related publications

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External links

No external links available for Gabrg2.

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*Gabrg2^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Gabrg2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Gabrg2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Gabrg2^{tm355(L1L2_gt2)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Gabrg2^{tm355(L1L2_st2)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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