Gabra2 | gamma-aminobutyric acid type A receptor subunit alpha 2

GeneMGI:95614Synonyms: C630048P16Rik, Gabra-2

Physiological systems

19 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Adipose tissue Growth/size/body region Vision/eye Behavior/neurological Cardiovascular system

13 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:15Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased locomotor activity1 supporting datasetGabra2em1(IMPC)HhomozygoteLate adult2x10-5 
limb grasping1 supporting datasetGabra2em1(IMPC)HhomozygoteLate adult1.5x10-6 
cornea opacity1 supporting datasetGabra2em1(IMPC)HhomozygoteEarly adult7.82x10-7 
decreased locomotor activity3 supporting datasetsGabra2em1(IMPC)HhomozygoteEarly adult9.6x10-9 
trunk curl1 supporting datasetGabra2em1(IMPC)HhomozygoteEarly adult8.43x10-6 
decreased heart rate1 supporting datasetGabra2em1(IMPC)HhomozygoteEarly adult2.97x10-5 
limb grasping1 supporting datasetGabra2em1(IMPC)HhomozygoteMiddle aged adult9.59x10-5 
decreased total body fat amount1 supporting datasetGabra2em1(IMPC)HhomozygoteLate adult1.02x10-6 
decreased exploration in new environment1 supporting datasetGabra2em1(IMPC)HhomozygoteLate adult3.83x10-5 
increased lean body mass1 supporting datasetGabra2em1(IMPC)HhomozygoteLate adult5.03x10-7 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Gabra2em1(IMPC)HExon Deletionmouse

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