Gabpa | GA repeat binding protein, alpha

GeneMGI:95610Synonyms: GABPalpha

Physiological systems

23 / 24 physiological systems tested

11 Significantly impacted by the knock-out

 Homeostasis/metabolism Embryo Growth/size/body region Digestive/alimentary Hearing/vestibular/ear Vision/eye Nervous system Skeleton Cardiovascular system Craniofacial Mortality/aging

12 No significant impact

1 Not tested

Gene metrics:12Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal craniofacial morphology1 supporting datasetGabpaem2(IMPC)MbphomozygoteE15.5N/A * 
cleft palate1 supporting datasetGabpaem2(IMPC)MbphomozygoteE15.5N/A * 
abnormal cranium morphology1 supporting datasetGabpaem2(IMPC)MbphomozygoteE12.5N/A * 
preweaning lethality, complete penetrance3 supporting datasetsGabpaem2(IMPC)MbphomozygoteEarly adultN/A * 
increased circulating bilirubin level1 supporting datasetGabpaem2(IMPC)MbpheterozygoteEarly adult1.24x10-7 
hemorrhage1 supporting datasetGabpaem2(IMPC)MbphomozygoteE15.5N/A * 
abnormal ear morphology1 supporting datasetGabpaem2(IMPC)MbphomozygoteE12.5N/A * 
spina bifida1 supporting datasetGabpaem2(IMPC)MbphomozygoteE15.5N/A * 
anophthalmia1 supporting datasetGabpaem2(IMPC)MbphomozygoteE15.5N/A * 
hemorrhage1 supporting datasetGabpaem2(IMPC)MbpheterozygoteE15.5N/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Gabpaem2(IMPC)MbpIndelmouse
Gabpatm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell

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