Fshr | follicle stimulating hormone receptor
Physiological systems
15 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Pigmentation Adipose tissue Growth/size/body region Vision/eye Behavior/neurological Skeleton
8 No significant impact
9 Not tested
Data collections
Gene metrics:7Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased lean body mass | 1 supporting dataset | Fshrtm1(KOMP)Vlcg | homozygote | Early adult | 8.46x10-8 | ||
| abnormal startle reflex | 1 supporting dataset | Fshrtm1(KOMP)Vlcg | homozygote | Early adult | 9.45x10-5 | ||
| increased total body fat amount | 2 supporting datasets | Fshrtm1(KOMP)Vlcg | homozygote | Early adult | 1.25x10-7 | ||
| decreased bone mineral content | 2 supporting datasets | Fshrtm1(KOMP)Vlcg | homozygote | Early adult | 1.98x10-11 | ||
| decreased bone mineral density | 1 supporting dataset | Fshrtm1(KOMP)Vlcg | homozygote | Early adult | 2.3x10-5 | ||
| abnormal iris pigmentation | 1 supporting dataset | Fshrtm1(KOMP)Vlcg | homozygote | Early adult | 9.81x10-5 | ||
| increased fasting circulating glucose level | 1 supporting dataset | Fshrtm1(KOMP)Vlcg | homozygote | Early adult | 2.9x10-5 |
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Human diseases caused by Fshr mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Fshr.
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| Fshrtm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Fshrtm371386(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |