Fshr | follicle stimulating hormone receptor

GeneMGI:95583Synonyms: follicle-stimulating hormone receptor, FSH-R, +1 more

Physiological systems

15 / 24 physiological systems tested

7 Significantly impacted by the knock-out

 Homeostasis/metabolism Pigmentation Adipose tissue Growth/size/body region Vision/eye Behavior/neurological Skeleton

8 No significant impact

9 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:7Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased lean body mass1 supporting datasetFshrtm1(KOMP)VlcghomozygoteEarly adult8.46x10-8 
abnormal startle reflex1 supporting datasetFshrtm1(KOMP)VlcghomozygoteEarly adult9.45x10-5 
increased total body fat amount2 supporting datasetsFshrtm1(KOMP)VlcghomozygoteEarly adult1.25x10-7 
decreased bone mineral content2 supporting datasetsFshrtm1(KOMP)VlcghomozygoteEarly adult1.98x10-11 
decreased bone mineral density1 supporting datasetFshrtm1(KOMP)VlcghomozygoteEarly adult2.3x10-5 
abnormal iris pigmentation1 supporting datasetFshrtm1(KOMP)VlcghomozygoteEarly adult9.81x10-5 
increased fasting circulating glucose level1 supporting datasetFshrtm1(KOMP)VlcghomozygoteEarly adult2.9x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

Human diseases caused by Fshr mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.






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Histopathology

IMPC related publications

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Fshrtm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Fshrtm371386(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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