Folr1 | folate receptor alpha

GeneMGI:95568Synonyms: folate-binding protein 1, Folbp1, +3 more

Physiological systems

21 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Embryo Growth/size/body region Cardiovascular system Mortality/aging Renal/urinary system

13 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

2Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



embryonic lethality prior to tooth bud stage	1 supporting dataset	Folr1^{tm1.1(KOMP)Vlcg}	homozygote	E12.5	N/A ^*
embryonic growth retardation	1 supporting dataset	Folr1^{tm1.1(KOMP)Vlcg}	homozygote	E9.5	N/A ^*
increased circulating alanine transaminase level	1 supporting dataset	Folr1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	6.91x10^-5
enlarged heart	1 supporting dataset	Folr1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
abnormal kidney morphology	1 supporting dataset	Folr1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Folr1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
small testis	1 supporting dataset	Folr1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
abnormal cholesterol homeostasis	1 supporting dataset	Folr1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	1.36x10^-10

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Folr1.

Associated images

Loading...

Histopathology

There is no histopathology data found for Folr1.

IMPC related publications

Loading...

External links

No external links available for Folr1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Folr1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Folr1^{tm1(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Folr1^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse

My Genes