Fcgr3 | Fc receptor, IgG, low affinity III

GeneMGI:95500Synonyms: FcgammaRIII, Fcg receptor III, +1 more

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Behavior/neurological Cardiovascular system

16 No significant impact

5 Not tested

Gene metrics:6Significant phenotypes
7Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues

Phenotypes

increased anxiety-related response1 supporting datasetFcgr3tm1b(EUCOMM)HmguhomozygoteEarly adult3.78x10-5 
increased heart rate1 supporting datasetFcgr3tm1b(EUCOMM)HmguhomozygoteLate adult1.36x10-5 
decreased circulating creatine kinase level1 supporting datasetFcgr3tm1b(EUCOMM)HmguhomozygoteLate adult7.04x10-11 
prolonged QT interval1 supporting datasetFcgr3tm1b(EUCOMM)HmguhomozygoteLate adult1.28x10-6 
tremors1 supporting datasetFcgr3tm1b(EUCOMM)HmguhomozygoteEarly adult1.9x10-9 
abnormal gait1 supporting datasetFcgr3tm1b(EUCOMM)HmguhomozygoteEarly adult1.4x10-8 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Fcgr3tm1.1(EGFP_CreERT2)WtsiReporter-tagged deletion allele (post Cre, with no selection cassette)ES Cell
Fcgr3tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Fcgr3tm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Fcgr3tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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