Fbn1 | fibrillin 1

GeneMGI:95489Synonyms: Fib-1

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Immune system Growth/size/body region Hematopoietic system Mortality/aging

13 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

19Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased spleen weight	1 supporting dataset	Fbn1^em1(IMPC)H	heterozygote	Early adult	1.24x10^-30
decreased lymphocyte cell number	1 supporting dataset	Fbn1^em1(IMPC)H	heterozygote	Early adult	1.03x10^-5
increased neutrophil cell number	2 supporting datasets	Fbn1^em1(IMPC)H	heterozygote	Early adult	6.93x10^-7
increased mean platelet volume	1 supporting dataset	Fbn1^em1(IMPC)H	heterozygote	Early adult	4.85x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Fbn1^em1(IMPC)H	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Fbn1.

Associated images

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Histopathology

There is no histopathology data found for Fbn1.

IMPC related publications

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External links

No external links available for Fbn1.

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*Fbn1^em1(IMPC)H*	Inter-exon deletion	‌	mouse
*Fbn1^{tm39432(L1L2_st2)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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