Fah | fumarylacetoacetate hydrolase

GeneMGI:95482Synonyms: swst

Physiological systems

22 / 24 physiological systems tested

13 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Integument Embryo Growth/size/body region Vision/eye Liver/biliary system Hematopoietic system Mortality/aging Cardiovascular system Renal/urinary system

9 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:21Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal kidney morphology	2 supporting datasets	Fah^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Fah^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal placenta vasculature	1 supporting dataset	Fah^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
embryonic growth retardation	1 supporting dataset	Fah^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
small liver	1 supporting dataset	Fah^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
persistence of hyaloid vascular system	1 supporting dataset	Fah^em1(IMPC)Mbp	heterozygote	Early adult	4.81x10^-6
abnormal retina vasculature morphology	1 supporting dataset	Fah^em1(IMPC)Mbp	heterozygote	Early adult	2.15x10^-6
abnormal blood vessel morphology	1 supporting dataset	Fah^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal placenta morphology	1 supporting dataset	Fah^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
enlarged testis	1 supporting dataset	Fah^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Fah.

Associated images

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Histopathology

There is no histopathology data found for Fah.

IMPC related publications

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External links

No external links available for Fah.

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*Fah^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Fah^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Fah^{tm43479(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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