Ercc3 | excision repair cross-complementing rodent repair deficiency, complementation group 3
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Nervous system Hematopoietic system Mortality/aging
15 No significant impact
5 Not tested
Data collections
Gene metrics:6Significant phenotypes
5Associated diseases
Expression examined in:0Adult tissues
30Embryo tissues
| embryonic lethality prior to organogenesis | 1 supporting dataset | Ercc3tm1b(NCOM)Mfgc | homozygote | E9.5 | N/A * | ||
| decreased prepulse inhibition | 2 supporting datasets | Ercc3tm1b(NCOM)Mfgc | heterozygote | Early adult | 3.99x10-7 | ||
| increased circulating potassium level | 1 supporting dataset | Ercc3tm1b(NCOM)Mfgc | heterozygote | Early adult | 1.16x10-5 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Ercc3tm1b(NCOM)Mfgc | homozygote | Early adult | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Ercc3tm1b(NCOM)Mfgc | homozygote | E12.5 | N/A * | ||
| decreased mean corpuscular hemoglobin | 1 supporting dataset | Ercc3tm1b(NCOM)Mfgc | heterozygote | Early adult | 1.91x10-5 |
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External links
No external links available for Ercc3.
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| Ercc3tm1a(NCOM)Mfgc | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ercc3tm1b(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | mouse |