Emx1 | empty spiracles homeobox 1

Physiological systems

21 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Reproductive system Adipose tissue Growth/size/body region Nervous system Behavior/neurological Skeleton Mortality/aging

14 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased brain weight	1 supporting dataset	Emx1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.93x10^-6
decreased grip strength	1 supporting dataset	Emx1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.77x10^-5
increased bone mineral content	2 supporting datasets	Emx1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.33x10^-8
female infertility	1 supporting dataset	Emx1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
decreased total body fat amount	1 supporting dataset	Emx1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.73x10^-6
abnormal bone structure	1 supporting dataset	Emx1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	8.88x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Emx1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
increased lean body mass	1 supporting dataset	Emx1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	5.37x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Emx1.

Associated images

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Histopathology

There is no histopathology data found for Emx1.

IMPC related publications

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External links

No external links available for Emx1.

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*Emx1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Emx1^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Emx1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Emx1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Emx1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Emx1^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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