Egr1 | early growth response 1
Physiological systems
20 / 24 physiological systems tested
11 Significantly impacted by the knock-out
Reproductive system Immune system Endocrine/exocrine gland Embryo Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Hematopoietic system Skeleton Mortality/aging
9 No significant impact
4 Not tested
Gene metrics:18Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
60Embryo tissues
| abnormal hindbrain development | 1 supporting dataset | Egr1tm1b(NCOM)Mfgc | homozygote | E9.5 | N/A * | ||
| male infertility | 1 supporting dataset | Egr1tm1b(NCOM)Mfgc | homozygote | Early adult | N/A * | ||
| short tibia | 1 supporting dataset | Egr1tm1b(NCOM)Mfgc | heterozygote | Early adult | 8.95x10-6 | ||
| small uterus | 1 supporting dataset | Egr1tm1b(NCOM)Mfgc | homozygote | Early adult | N/A * | ||
| increased lymphocyte cell number | 1 supporting dataset | Egr1tm1b(NCOM)Mfgc | heterozygote | Early adult | 1.7x10-5 | ||
| absent seminal vesicle | 1 supporting dataset | Egr1tm1b(NCOM)Mfgc | homozygote | Early adult | N/A * | ||
| abnormal midbrain development | 1 supporting dataset | Egr1tm1b(NCOM)Mfgc | homozygote | E9.5 | N/A * | ||
| abnormal optic disk morphology | 1 supporting dataset | Egr1tm1b(NCOM)Mfgc | homozygote | Early adult | 2.34x10-5 | ||
| preweaning lethality, incomplete penetrance | 3 supporting datasets | Egr1tm1b(NCOM)Mfgc | homozygote | Early adult | N/A * | ||
| abnormal forebrain development | 1 supporting dataset | Egr1tm1b(NCOM)Mfgc | homozygote | E9.5 | N/A * |
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Human diseases caused by Egr1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Egr1.
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| Egr1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Egr1tm1a(NCOM)Mfgc | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Egr1tm1b(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Egr1tm214497(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |