Ebf1 | early B cell factor 1
Physiological systems
22 / 24 physiological systems tested
12 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Integument Embryo Growth/size/body region Nervous system Liver/biliary system Hematopoietic system Behavior/neurological Mortality/aging Cardiovascular system Renal/urinary system
10 No significant impact
2 Not tested
Data collections
Gene metrics:11Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased prepulse inhibition | 3 supporting datasets | Ebf1em1(IMPC)Mbp | heterozygote | Early adult | 2x10-6 | ||
| increased circulating serum albumin level | 1 supporting dataset | Ebf1em1(IMPC)Mbp | heterozygote | Early adult | 4.04x10-5 | ||
| enlarged lymph nodes | 1 supporting dataset | Ebf1em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| preweaning lethality, incomplete penetrance | 3 supporting datasets | Ebf1em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| enlarged kidney | 1 supporting dataset | Ebf1em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| enlarged heart | 1 supporting dataset | Ebf1em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| no spontaneous movement | 1 supporting dataset | Ebf1em1(IMPC)Mbp | homozygote | E18.5 | N/A * | ||
| abnormal skin morphology | 1 supporting dataset | Ebf1em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| abnormal liver morphology | 1 supporting dataset | Ebf1em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| no spontaneous movement | 1 supporting dataset | Ebf1em1(IMPC)Mbp | heterozygote | E18.5 | N/A * |
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Human diseases caused by Ebf1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Ebf1.
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| Ebf1em1(IMPC)Mbp | Exon Deletion | | mouse |
| Ebf1tm254(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |