Ebf1 | early B cell factor 1

GeneMGI:95275Synonyms: O/E-1, Olf1, +1 more

Physiological systems

22 / 24 physiological systems tested

12 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Embryo Growth/size/body region Nervous system Liver/biliary system Hematopoietic system Behavior/neurological Mortality/aging Cardiovascular system Renal/urinary system

10 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased prepulse inhibition	3 supporting datasets	Ebf1^em1(IMPC)Mbp	heterozygote	Early adult	2x10^-6
increased circulating serum albumin level	1 supporting dataset	Ebf1^em1(IMPC)Mbp	heterozygote	Early adult	4.04x10^-5
enlarged lymph nodes	1 supporting dataset	Ebf1^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
preweaning lethality, incomplete penetrance	3 supporting datasets	Ebf1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
enlarged kidney	1 supporting dataset	Ebf1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
enlarged heart	1 supporting dataset	Ebf1^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
no spontaneous movement	1 supporting dataset	Ebf1^em1(IMPC)Mbp	homozygote	E18.5	N/A ^*
abnormal skin morphology	1 supporting dataset	Ebf1^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
abnormal liver morphology	1 supporting dataset	Ebf1^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
no spontaneous movement	1 supporting dataset	Ebf1^em1(IMPC)Mbp	heterozygote	E18.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ebf1.

Associated images

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Histopathology

There is no histopathology data found for Ebf1.

IMPC related publications

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External links

No external links available for Ebf1.

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*Ebf1^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Ebf1^{tm254(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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