Ebf1 | early B cell factor 1

GeneMGI:95275Synonyms: O/E-1, Olf1, +1 more

Physiological systems

22 / 24 physiological systems tested

12 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Integument Embryo Growth/size/body region Nervous system Liver/biliary system Hematopoietic system Behavior/neurological Mortality/aging Cardiovascular system Renal/urinary system

10 No significant impact

2 Not tested

Gene metrics:11Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased prepulse inhibition3 supporting datasetsEbf1em1(IMPC)MbpheterozygoteEarly adult2x10-6 
increased circulating serum albumin level1 supporting datasetEbf1em1(IMPC)MbpheterozygoteEarly adult4.04x10-5 
enlarged lymph nodes1 supporting datasetEbf1em1(IMPC)MbpheterozygoteLate adultN/A * 
preweaning lethality, incomplete penetrance3 supporting datasetsEbf1em1(IMPC)MbphomozygoteEarly adultN/A * 
enlarged kidney1 supporting datasetEbf1em1(IMPC)MbpheterozygoteEarly adultN/A * 
enlarged heart1 supporting datasetEbf1em1(IMPC)MbpheterozygoteLate adultN/A * 
no spontaneous movement1 supporting datasetEbf1em1(IMPC)MbphomozygoteE18.5N/A * 
abnormal skin morphology1 supporting datasetEbf1em1(IMPC)MbpheterozygoteLate adultN/A * 
abnormal liver morphology1 supporting datasetEbf1em1(IMPC)MbpheterozygoteLate adultN/A * 
no spontaneous movement1 supporting datasetEbf1em1(IMPC)MbpheterozygoteE18.5N/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Human diseases caused by Ebf1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.






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Histopathology

IMPC related publications

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Ebf1em1(IMPC)MbpExon Deletionmouse
Ebf1tm254(L1L2_gt0)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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