Dmp1 | dentin matrix protein 1
GeneMGI:94910
Physiological systems
21 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Growth/size/body region Behavior/neurological Skeleton Cardiovascular system Renal/urinary system
14 No significant impact
3 Not tested
Data collections
Gene metrics:18Significant phenotypes
2Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| decreased bone mineral density | 1 supporting dataset | Dmp1tm1.1(KOMP)Vlcg | homozygote | Early adult | 5.01x10-18 | ||
| decreased bone mineral content | 2 supporting datasets | Dmp1tm1.1(KOMP)Vlcg | homozygote | Early adult | 9.69x10-20 | ||
| decreased body length | 1 supporting dataset | Dmp1tm1.1(KOMP)Vlcg | homozygote | Early adult | 2.03x10-26 | ||
| increased lean body mass | 1 supporting dataset | Dmp1tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.25x10-5 | ||
| decreased grip strength | 4 supporting datasets | Dmp1tm1.1(KOMP)Vlcg | homozygote | Early adult | 6.06x10-19 | ||
| decreased heart rate | 1 supporting dataset | Dmp1tm1.1(KOMP)Vlcg | homozygote | Early adult | 7.18x10-12 | ||
| enlarged kidney | 1 supporting dataset | Dmp1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Dmp1tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.05x10-193 | ||
| abnormal kidney morphology | 1 supporting dataset | Dmp1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| increased total body fat amount | 1 supporting dataset | Dmp1tm1.1(KOMP)Vlcg | homozygote | Early adult | 2.96x10-5 |
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| adrenal gland | heterozygote | Section images | 100% (1/1) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/1) | 0% (0/17) |
| bone marrow | heterozygote | Section images | 100% (2/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | Section images | 100% (1/1) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Dmp1.
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| Dmp1tm1(EGFP_CreERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Dmp1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Dmp1tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Dmp1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Dmp1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Dmp1tm2(EGFP/cre/ERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |