Dmp1 | dentin matrix protein 1

Physiological systems

21 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Behavior/neurological Skeleton Cardiovascular system Renal/urinary system

14 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:18Significant phenotypes

2Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased bone mineral density	1 supporting dataset	Dmp1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	5.01x10^-18
decreased bone mineral content	2 supporting datasets	Dmp1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	9.69x10^-20
decreased body length	1 supporting dataset	Dmp1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.03x10^-26
increased lean body mass	1 supporting dataset	Dmp1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.25x10^-5
decreased grip strength	4 supporting datasets	Dmp1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	6.06x10^-19
decreased heart rate	1 supporting dataset	Dmp1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	7.18x10^-12
enlarged kidney	1 supporting dataset	Dmp1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
increased circulating alkaline phosphatase level	1 supporting dataset	Dmp1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.05x10^-193
abnormal kidney morphology	1 supporting dataset	Dmp1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
increased total body fat amount	1 supporting dataset	Dmp1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.96x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dmp1.

Associated images

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Histopathology

There is no histopathology data found for Dmp1.

IMPC related publications

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External links

No external links available for Dmp1.

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*Dmp1^{tm1(EGFP_CreERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Dmp1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Dmp1^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Dmp1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Dmp1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Dmp1^{tm2(EGFP/cre/ERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse

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