Dmd | dystrophin, muscular dystrophy

GeneMGI:94909Synonyms: Dp71, Dp427, +5 more

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Skeleton

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:14Significant phenotypes
8Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased lean body mass2 supporting datasetsDmdem1(IMPC)HmguhomozygoteEarly adult6.88x10-15 
increased circulating alkaline phosphatase level1 supporting datasetDmdem1(IMPC)HmguhomozygoteEarly adult3.95x10-5 
increased circulating aspartate transaminase level1 supporting datasetDmdem1(IMPC)HmguhomozygoteEarly adult0 
decreased bone mineral content2 supporting datasetsDmdem1(IMPC)HmguhomozygoteEarly adult3.13x10-14 
increased circulating aspartate transaminase level1 supporting datasetDmdem1(IMPC)HmguhemizygoteEarly adult1.88x10-56 
decreased total body fat amount2 supporting datasetsDmdem1(IMPC)HmguhemizygoteEarly adult5.88x10-6 
increased circulating total protein level1 supporting datasetDmdem1(IMPC)HmguhomozygoteEarly adult8x10-7 
increased lean body mass2 supporting datasetsDmdem1(IMPC)HmguhemizygoteEarly adult3.25x10-6 
thrombocytosis1 supporting datasetDmdem1(IMPC)HmguhomozygoteEarly adult7.68x10-10 
increased circulating serum albumin level1 supporting datasetDmdem1(IMPC)HmguhomozygoteEarly adult2.35x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Human diseases caused by Dmd mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.






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Histopathology

IMPC related publications

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Dmdem1(IMPC)HmguExon Deletionmouse
Dmdtm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell
Dmdtm82520(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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