Dlk1 | delta like non-canonical Notch ligand 1
Physiological systems
18 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Growth/size/body region Hematopoietic system Mortality/aging
13 No significant impact
6 Not tested
Data collections
Gene metrics:5Significant phenotypes
8Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased circulating glucose level | 1 supporting dataset | Dlk1em1(IMPC)Wtsi | homozygote | Early adult | 8.85x10-6 | ||
| increased mean corpuscular hemoglobin | 1 supporting dataset | Dlk1em1(IMPC)Wtsi | homozygote | Early adult | 9.51x10-5 | ||
| decreased lean body mass | 1 supporting dataset | Dlk1em1(IMPC)Wtsi | homozygote | Early adult | 1.46x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Dlk1em1(IMPC)Wtsi | homozygote | Early adult | N/A * | ||
| increased total body fat amount | 1 supporting dataset | Dlk1em1(IMPC)Wtsi | homozygote | Early adult | 6.59x10-6 |
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Human diseases caused by Dlk1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Dlk1.
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| Dlk1em1(IMPC)Wtsi | Deletion | | mouse |
| Dlk1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Dlk1tm214456(L1L2_Bact_P) | Reporter-tagged deletion allele (with selection cassette) | | targeting vector |