Dlk1 | delta like non-canonical Notch ligand 1

GeneMGI:94900Synonyms: pref-1, DlkI, +5 more

Physiological systems

18 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Hematopoietic system Mortality/aging

13 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

8Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased circulating glucose level	1 supporting dataset	Dlk1^{em1(IMPC)Wtsi}	homozygote	Early adult	8.85x10^-6
increased mean corpuscular hemoglobin	1 supporting dataset	Dlk1^{em1(IMPC)Wtsi}	homozygote	Early adult	9.51x10^-5
decreased lean body mass	1 supporting dataset	Dlk1^{em1(IMPC)Wtsi}	homozygote	Early adult	1.46x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Dlk1^{em1(IMPC)Wtsi}	homozygote	Early adult	N/A ^*
increased total body fat amount	1 supporting dataset	Dlk1^{em1(IMPC)Wtsi}	homozygote	Early adult	6.59x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dlk1.

Associated images

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Histopathology

There is no histopathology data found for Dlk1.

IMPC related publications

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External links

No external links available for Dlk1.

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*Dlk1^{em1(IMPC)Wtsi}*	Deletion	‌	mouse
*Dlk1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Dlk1^{tm214456(L1L2_Bact_P)}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector

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