Dhfr | dihydrofolate reductase
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Nervous system Hematopoietic system Mortality/aging
15 No significant impact
5 Not tested
Data collections
Gene metrics:6Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
29Embryo tissues
| preweaning lethality, complete penetrance | 3 supporting datasets | Dhfrtm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| decreased mean corpuscular hemoglobin | 1 supporting dataset | Dhfrtm1b(EUCOMM)Wtsi | heterozygote | Early adult | 7.65x10-5 | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Dhfrtm1b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * | ||
| decreased circulating creatinine level | 1 supporting dataset | Dhfrtm1b(EUCOMM)Wtsi | heterozygote | Early adult | 5.89x10-6 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Dhfrtm1b(EUCOMM)Wtsi | homozygote | E9.5 | N/A * | ||
| decreased prepulse inhibition | 1 supporting dataset | Dhfrtm1b(EUCOMM)Wtsi | heterozygote | Early adult | 7.01x10-8 |
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External links
No external links available for Dhfr.
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| Dhfrtm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Dhfrtm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Dhfrtm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Dhfrtm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Dhfrtm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Dhfrtm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |