Dhfr | dihydrofolate reductase
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Nervous system Hematopoietic system Mortality/aging
15 No significant impact
5 Not tested
Data collections
Gene metrics:6Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
29Embryo tissues
| preweaning lethality, complete penetrance | 3 supporting datasets | Dhfrtm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| decreased mean corpuscular hemoglobin | 1 supporting dataset | Dhfrtm1b(EUCOMM)Wtsi | heterozygote | Early adult | 7.65x10-5 | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Dhfrtm1b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * | ||
| decreased circulating creatinine level | 1 supporting dataset | Dhfrtm1b(EUCOMM)Wtsi | heterozygote | Early adult | 5.89x10-6 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Dhfrtm1b(EUCOMM)Wtsi | homozygote | E9.5 | N/A * | ||
| decreased prepulse inhibition | 1 supporting dataset | Dhfrtm1b(EUCOMM)Wtsi | heterozygote | Early adult | 7.01x10-8 |
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Human diseases caused by Dhfr mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Dhfr.
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| Dhfrtm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Dhfrtm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Dhfrtm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Dhfrtm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Dhfrtm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Dhfrtm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |