Bach1 | BTB and CNC homology 1, basic leucine zipper transcription factor 1
Physiological systems
17 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Skeleton Cardiovascular system Mortality/aging
12 No significant impact
7 Not tested
Data collections
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:49Adult tissues
46Embryo tissues
| increased bone mineral density | 1 supporting dataset | Bach1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 8.33x10-5 | ||
| increased circulating sodium level | 1 supporting dataset | Bach1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 2.45x10-6 | ||
| increased heart rate variability | 1 supporting dataset | Bach1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 3.81x10-6 | ||
| cardiovascular system phenotype | 1 supporting dataset | Bach1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 6.16x10-8 | ||
| increased heart weight | 1 supporting dataset | Bach1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 5.24x10-7 | ||
| increased fasting circulating glucose level | 1 supporting dataset | Bach1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 1.04x10-16 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Bach1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| increased bone mineral content | 1 supporting dataset | Bach1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 1.83x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| bone marrow | heterozygote | Section images | 100% (2/2) | 0% (0/22) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
Human diseases caused by Bach1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Bach1.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Bach1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Bach1tm1(NCOM)Cmhd | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Bach1tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Bach1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Bach1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |