Aurka | aurora kinase A
Physiological systems
20 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Immune system Vision/eye Hematopoietic system Skeleton Mortality/aging
15 No significant impact
4 Not tested
Data collections
Gene metrics:6Significant phenotypes
1Associated diseases
Expression examined in:49Adult tissues
25Embryo tissues
| embryonic lethality prior to organogenesis | 1 supporting dataset | Aurkatm1b(EUCOMM)Hmgu | homozygote | E9.5 | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Aurkatm1b(EUCOMM)Hmgu | homozygote | E12.5 | N/A * | ||
| decreased leukocyte cell number | 1 supporting dataset | Aurkatm1b(EUCOMM)Hmgu | heterozygote | Early adult | 5.78x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Aurkatm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| abnormal bone structure | 1 supporting dataset | Aurkatm1b(EUCOMM)Hmgu | heterozygote | Early adult | 3.4x10-5 | ||
| sclerocornea | 1 supporting dataset | Aurkatm1b(EUCOMM)Hmgu | heterozygote | Early adult | 7.52x10-5 |
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External links
No external links available for Aurka.
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| Aurkatm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Aurkatm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Aurkatm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |