Cacnb2 | calcium channel, voltage-dependent, beta 2 subunit

GeneMGI:894644Synonyms: Cavbeta2, Cchb2

Physiological systems

18 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Homeostasis/metabolism Renal/urinary system

16 No significant impact

6 Not tested

Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues

Phenotypes

increased circulating glucose level1 supporting datasetCacnb2tm1.1(KOMP)VlcghomozygoteEarly adult4.78x10-5 
impaired glucose tolerance2 supporting datasetsCacnb2tm1.1(KOMP)VlcghomozygoteEarly adult2.85x10-14 
abnormal urinary bladder morphology1 supporting datasetCacnb2tm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Cacnb2tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Cacnb2tm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse
Cacnb2tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Cacnb2tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell
Cacnb2tm39259(L1L2_gt0)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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