Cacnb2 | calcium channel, voltage-dependent, beta 2 subunit
Physiological systems
18 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Homeostasis/metabolism Renal/urinary system
16 No significant impact
6 Not tested
Data collections
Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| increased circulating glucose level | 1 supporting dataset | Cacnb2tm1.1(KOMP)Vlcg | homozygote | Early adult | 4.78x10-5 | ||
| impaired glucose tolerance | 2 supporting datasets | Cacnb2tm1.1(KOMP)Vlcg | homozygote | Early adult | 2.85x10-14 | ||
| abnormal urinary bladder morphology | 1 supporting dataset | Cacnb2tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/1) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | Section images | 50% (1/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | Section images | 50% (1/2) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
Human diseases caused by Cacnb2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Cacnb2.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Cacnb2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Cacnb2tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Cacnb2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Cacnb2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Cacnb2tm39259(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |