Cyp17a1 | cytochrome P450, family 17, subfamily a, polypeptide 1

GeneMGI:88586Synonyms: p450c17, steroid 17-alpha hydroxylase, +1 more

Physiological systems

16 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Adipose tissue Growth/size/body region Hearing/vestibular/ear Behavior/neurological Skeleton Cardiovascular system

8 No significant impact

8 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:20Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased circulating phosphate level	1 supporting dataset	Cyp17a1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.95x10^-5
decreased bone mineral content	2 supporting datasets	Cyp17a1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.76x10^-28
decreased lean body mass	2 supporting datasets	Cyp17a1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.82x10^-22
decreased locomotor activity	4 supporting datasets	Cyp17a1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	7.5x10^-11
improved glucose tolerance	1 supporting dataset	Cyp17a1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.21x10^-6
increased blood urea nitrogen level	1 supporting dataset	Cyp17a1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.21x10^-5
increased fasting circulating glucose level	1 supporting dataset	Cyp17a1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.63x10^-25
increased total body fat amount	2 supporting datasets	Cyp17a1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	6.03x10^-23
increased circulating cholesterol level	1 supporting dataset	Cyp17a1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.77x10^-7
decreased bone mineral density	1 supporting dataset	Cyp17a1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.74x10^-19

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cyp17a1.

Associated images

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Histopathology

There is no histopathology data found for Cyp17a1.

IMPC related publications

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External links

No external links available for Cyp17a1.

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*Cyp17a1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Cyp17a1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Cyp17a1^{tm42149(L1L2_st0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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