Ctsd | cathepsin D
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Vision/eye Hematopoietic system Mortality/aging
15 No significant impact
5 Not tested
Data collections
Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased hematocrit | 1 supporting dataset | Ctsdtm1b(EUCOMM)Wtsi | heterozygote | Early adult | 6.65x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Ctsdtm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| cornea opacity | 1 supporting dataset | Ctsdtm1b(EUCOMM)Wtsi | heterozygote | Early adult | 7.35x10-5 | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Ctsdtm1b(EUCOMM)Wtsi | heterozygote | Early adult | 4.48x10-11 |
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Human diseases caused by Ctsd mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ctsd.
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| Ctsdtm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Ctsdtm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ctsdtm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ctsdtm41779(L1L2_st1) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |