Cs | citrate synthase

GeneMGI:88529Synonyms: 9030605P22Rik, Cis, +2 more

Physiological systems

18 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Limbs/digits/tail Nervous system Behavior/neurological Mortality/aging

13 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased prepulse inhibition1 supporting datasetCstm1.1(KOMP)WtsiheterozygoteEarly adult5.19x10-5 
preweaning lethality, complete penetrance1 supporting datasetCstm1.1(KOMP)WtsihomozygoteEarly adultN/A * 
impaired glucose tolerance1 supporting datasetCstm1.1(KOMP)WtsiheterozygoteEarly adult3.79x10-6 
decreased grip strength1 supporting datasetCstm1.1(KOMP)WtsiheterozygoteEarly adult5.1x10-5 
abnormal digit morphology1 supporting datasetCstm1.1(KOMP)WtsiheterozygoteEarly adult2.16x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Cstm1(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)targeting vector
ES Cell
mouse
Cstm1.1(KOMP)WtsiReporter-tagged deletion allele (post Cre, with no selection cassette)mouse
Cstm455803(L1L2_GT0_LF2A_LacZ_BetactP_neo)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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