Crygc | crystallin, gamma C
Physiological systems
21 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Endocrine/exocrine gland Growth/size/body region Mortality/aging Cardiovascular system
17 No significant impact
3 Not tested
Data collections
Gene metrics:3Significant phenotypes
5Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| abnormal pancreas morphology | 1 supporting dataset | Crygctm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| enlarged heart | 1 supporting dataset | Crygctm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Crygctm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
Human diseases caused by Crygc mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Crygc.
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| Crygctm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Crygctm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Crygctm271568(L1L2_Bact_P) | Reporter-tagged deletion allele (with selection cassette) | | targeting vector |
| Crygctm455783(L1L2_GT0_LF2A_LacZ_BetactP_neo) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |