Cp | ceruloplasmin
Physiological systems
18 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Hematopoietic system Behavior/neurological Cardiovascular system
13 No significant impact
6 Not tested
Data collections
Gene metrics:9Significant phenotypes
2Associated diseases
Expression examined in:48Adult tissues
52Embryo tissues
| decreased mean corpuscular hemoglobin concentration | 1 supporting dataset | Cptm1b(KOMP)Wtsi | homozygote | Early adult | 4.06x10-8 | ||
| decreased circulating iron level | 1 supporting dataset | Cptm1b(KOMP)Wtsi | homozygote | Early adult | 1.16x10-8 | ||
| hypoalgesia | 1 supporting dataset | Cptm1b(KOMP)Wtsi | homozygote | Early adult | 6.08x10-5 ** | ||
| decreased mean corpuscular hemoglobin | 2 supporting datasets | Cptm1b(KOMP)Wtsi | homozygote | Early adult | 0 | ||
| decreased mean corpuscular volume | 1 supporting dataset | Cptm1b(KOMP)Wtsi | homozygote | Early adult | 0 | ||
| decreased hemoglobin content | 1 supporting dataset | Cptm1b(KOMP)Wtsi | homozygote | Early adult | 1.86x10-10 | ||
| increased heart weight | 1 supporting dataset | Cptm1b(KOMP)Wtsi | homozygote | Early adult | 3.37x10-5 | ||
| abnormal sleep behavior | 1 supporting dataset | Cptm1b(KOMP)Wtsi | homozygote | Early adult | 2.27x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Cp mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Cp.
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| Cptm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Cptm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |