Comt | catechol-O-methyltransferase
Physiological systems
19 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Hematopoietic system Behavior/neurological
16 No significant impact
5 Not tested
Data collections
Gene metrics:13Significant phenotypes
3Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| decreased circulating serum albumin level | 1 supporting dataset | Comttm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.05x10-7 | ||
| decreased anxiety-related response | 1 supporting dataset | Comttm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.24x10-8 | ||
| decreased circulating fructosamine level | 1 supporting dataset | Comttm1b(EUCOMM)Wtsi | homozygote | Early adult | 4.61x10-11 | ||
| hyperactivity | 2 supporting datasets | Comttm1b(EUCOMM)Wtsi | homozygote | Early adult | 2x10-6 | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Comttm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.36x10-5 | ||
| decreased erythrocyte cell number | 1 supporting dataset | Comttm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.81x10-5 | ||
| decreased thigmotaxis | 2 supporting datasets | Comttm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.61x10-6 | ||
| abnormal locomotor behavior | 1 supporting dataset | Comttm1b(EUCOMM)Wtsi | homozygote | Early adult | 5.46x10-6 | ||
| increased circulating phosphate level | 1 supporting dataset | Comttm1b(EUCOMM)Wtsi | homozygote | Early adult | 8.85x10-5 | ||
| abnormal behavior | 1 supporting dataset | Comttm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.61x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Comt mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Comt.
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| Comttm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Comttm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Comttm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |