Comt | catechol-O-methyltransferase

GeneMGI:88470Synonyms: D16Wsu103e, Comt1, +1 more

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system Behavior/neurological

16 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

3Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



decreased circulating serum albumin level	1 supporting dataset	Comt^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.05x10^-7
decreased anxiety-related response	1 supporting dataset	Comt^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.24x10^-8
decreased circulating fructosamine level	1 supporting dataset	Comt^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.61x10^-11
hyperactivity	2 supporting datasets	Comt^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2x10^-6
increased circulating alanine transaminase level	1 supporting dataset	Comt^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.36x10^-5
decreased erythrocyte cell number	1 supporting dataset	Comt^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.81x10^-5
decreased thigmotaxis	2 supporting datasets	Comt^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.61x10^-6
abnormal locomotor behavior	1 supporting dataset	Comt^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.46x10^-6
increased circulating phosphate level	1 supporting dataset	Comt^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	8.85x10^-5
abnormal behavior	1 supporting dataset	Comt^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.61x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Comt.

Associated images

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Histopathology

There is no histopathology data found for Comt.

IMPC related publications

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External links

No external links available for Comt.

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*Comt^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Comt^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Comt^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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