Col1a2 | collagen, type I, alpha 2

GeneMGI:88468Synonyms: Col1a-2, Cola2, +1 more

Physiological systems

18 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

7 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:18Significant phenotypes

15Associated diseases

Expression examined in:49Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



increased heart weight	1 supporting dataset	Col1a2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.5x10^-8
enlarged heart	1 supporting dataset	Col1a2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased bone mineral content	1 supporting dataset	Col1a2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.04x10^-7
increased circulating alkaline phosphatase level	2 supporting datasets	Col1a2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	6.23x10^-16
increased neutrophil cell number	2 supporting datasets	Col1a2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.41x10^-6
increased bone mineral density	1 supporting dataset	Col1a2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.49x10^-6
decreased grip strength	4 supporting datasets	Col1a2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.36x10^-10
decreased total body fat amount	1 supporting dataset	Col1a2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	8.95x10^-5
enlarged spleen	1 supporting dataset	Col1a2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased large unstained cell number	2 supporting datasets	Col1a2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.25x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Col1a2.

Associated images

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Histopathology

There is no histopathology data found for Col1a2.

IMPC related publications

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External links

No external links available for Col1a2.

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*Col1a2^em1H*	Exon Deletion	‌	mouse
*Col1a2^em2H*	Exon Deletion	‌	mouse
*Col1a2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Col1a2^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Col1a2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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