Col6a3 | collagen, type VI, alpha 3

GeneMGI:88461Synonyms: Col6a-3

Physiological systems

18 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Behavior/neurological Cardiovascular system Renal/urinary system

12 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

8Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:



enlarged urinary bladder	1 supporting dataset	Col6a3^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
decreased body length	1 supporting dataset	Col6a3^em1(IMPC)Tcp	homozygote	Early adult	1.41x10^-5
decreased grip strength	1 supporting dataset	Col6a3^em1(IMPC)Tcp	homozygote	Early adult	2.92x10^-6
increased circulating LDL cholesterol level	1 supporting dataset	Col6a3^{em1(IMPC)Kmpc}	homozygote	Early adult	4.39x10^-5
enlarged lymph nodes	1 supporting dataset	Col6a3^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
prolonged QT interval	1 supporting dataset	Col6a3^em1(IMPC)Tcp	homozygote	Early adult	6.59x10^-5
decreased grip strength	1 supporting dataset	Col6a3^{em1(IMPC)Kmpc}	homozygote	Early adult	2.76x10^-5
enlarged kidney	1 supporting dataset	Col6a3^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
decreased lean body mass	1 supporting dataset	Col6a3^{em1(IMPC)Kmpc}	homozygote	Early adult	9.04x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Col6a3.

Associated images

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Histopathology

There is no histopathology data found for Col6a3.

IMPC related publications

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External links

No external links available for Col6a3.

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*Col6a3^{em1(IMPC)Kmpc}*	Exon Deletion	‌	mouse
*Col6a3^em1(IMPC)Tcp*	Intra-exon deletion	‌	mouse
*Col6a3^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell

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