Col11a2 | collagen, type XI, alpha 2

Physiological systems

19 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Hematopoietic system Behavior/neurological Cardiovascular system Mortality/aging

13 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

10Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased circulating bilirubin level	1 supporting dataset	Col11a2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.5x10^-7
preweaning lethality, incomplete penetrance	1 supporting dataset	Col11a2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased mean corpuscular volume	1 supporting dataset	Col11a2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	3.69x10^-6
decreased cardiac output	1 supporting dataset	Col11a2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.78x10^-5
increased lean body mass	1 supporting dataset	Col11a2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	8.3x10^-5
decreased circulating triglyceride level	1 supporting dataset	Col11a2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.33x10^-7
increased startle reflex	1 supporting dataset	Col11a2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	6.25x10^-6
increased circulating unsaturated transferrin level	1 supporting dataset	Col11a2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.7x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Col11a2.

Associated images

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Histopathology

There is no histopathology data found for Col11a2.

IMPC related publications

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External links

No external links available for Col11a2.

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*Col11a2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Col11a2^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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