F2 | coagulation factor II

GeneMGI:88380Synonyms: FII, Cf-2, +3 more

Physiological systems

17 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Skeleton Mortality/aging

10 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

6Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased circulating fructosamine level	1 supporting dataset	F2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	8.52x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	F2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased lean body mass	2 supporting datasets	F2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	4.18x10^-8
decreased exploration in new environment	1 supporting dataset	F2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.48x10^-8
tremors	1 supporting dataset	F2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.7x10^-6
decreased bone mineral content	2 supporting datasets	F2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.15x10^-6
increased circulating serum albumin level	1 supporting dataset	F2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.49x10^-5
decreased mean corpuscular volume	1 supporting dataset	F2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	8.99x10^-5
increased total body fat amount	2 supporting datasets	F2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.84x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for F2.

Associated images

Loading...

Histopathology

There is no histopathology data found for F2.

IMPC related publications

Loading...

External links

No external links available for F2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*F2^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector es cell
*F2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*F2^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*F2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

My Genes