Cd28 | CD28 antigen

GeneMGI:88327

Physiological systems

19 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Immune system Hematopoietic system

17 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased CD4-positive, alpha-beta T cell number	1 supporting dataset	Cd28^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	5.46x10^-7
decreased T cell number	1 supporting dataset	Cd28^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.08x10^-78
increased leukocyte cell number	1 supporting dataset	Cd28^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	3x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cd28.

Associated images

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Histopathology

There is no histopathology data found for Cd28.

IMPC related publications

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External links

No external links available for Cd28.

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*Cd28^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Cd28^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Cd28^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

My Genes