Ccnd2 | cyclin D2
Physiological systems
20 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Skeleton Craniofacial
11 No significant impact
4 Not tested
Data collections
Gene metrics:15Significant phenotypes
2Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| abnormal cranium morphology | 1 supporting dataset | Ccnd2tm1b(KOMP)Mbp | homozygote | Early adult | 5.08x10-9 | ||
| decreased total body fat amount | 1 supporting dataset | Ccnd2tm1b(KOMP)Mbp | homozygote | Late adult | 4.54x10-6 | ||
| increased circulating glucose level | 1 supporting dataset | Ccnd2tm1b(KOMP)Mbp | homozygote | Early adult | 1.9x10-8 | ||
| trunk curl | 1 supporting dataset | Ccnd2tm1b(KOMP)Mbp | homozygote | Middle aged adult | 2.09x10-5 | ||
| abnormal spine curvature | 1 supporting dataset | Ccnd2tm1b(KOMP)Mbp | homozygote | Late adult | 1.65x10-6 | ||
| increased circulating phosphate level | 1 supporting dataset | Ccnd2tm1b(KOMP)Mbp | homozygote | Late adult | 9.68x10-5 | ||
| increased fasting circulating glucose level | 1 supporting dataset | Ccnd2tm1b(KOMP)Mbp | homozygote | Early adult | 2.14x10-6 | ||
| abnormal spine curvature | 1 supporting dataset | Ccnd2tm1b(KOMP)Mbp | homozygote | Early adult | 1.13x10-10 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Ccnd2tm1b(KOMP)Mbp | homozygote | Late adult | 1.39x10-21 | ||
| small testis | 1 supporting dataset | Ccnd2tm1b(KOMP)Mbp | homozygote | Late adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Ccnd2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ccnd2.
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| Ccnd2tm1a(KOMP)Mbp | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ccnd2tm1b(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ccnd2tm1e(KOMP)Mbp | Targeted, non-conditional allele | | ES Cell |