Ccnd2 | cyclin D2

GeneMGI:88314Synonyms: Vin-1, cD2, +2 more

Physiological systems

20 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Skeleton Craniofacial

11 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:15Significant phenotypes

2Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:

Life Stage:



abnormal cranium morphology	1 supporting dataset	Ccnd2^{tm1b(KOMP)Mbp}	homozygote	Early adult	5.08x10^-9
decreased total body fat amount	1 supporting dataset	Ccnd2^{tm1b(KOMP)Mbp}	homozygote	Late adult	4.54x10^-6
increased circulating glucose level	1 supporting dataset	Ccnd2^{tm1b(KOMP)Mbp}	homozygote	Early adult	1.9x10^-8
trunk curl	1 supporting dataset	Ccnd2^{tm1b(KOMP)Mbp}	homozygote	Middle aged adult	2.09x10^-5
abnormal spine curvature	1 supporting dataset	Ccnd2^{tm1b(KOMP)Mbp}	homozygote	Late adult	1.65x10^-6
increased circulating phosphate level	1 supporting dataset	Ccnd2^{tm1b(KOMP)Mbp}	homozygote	Late adult	9.68x10^-5
increased fasting circulating glucose level	1 supporting dataset	Ccnd2^{tm1b(KOMP)Mbp}	homozygote	Early adult	2.14x10^-6
abnormal spine curvature	1 supporting dataset	Ccnd2^{tm1b(KOMP)Mbp}	homozygote	Early adult	1.13x10^-10
increased circulating alkaline phosphatase level	1 supporting dataset	Ccnd2^{tm1b(KOMP)Mbp}	homozygote	Late adult	1.39x10^-21
small testis	1 supporting dataset	Ccnd2^{tm1b(KOMP)Mbp}	homozygote	Late adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ccnd2.

Associated images

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Histopathology

There is no histopathology data found for Ccnd2.

IMPC related publications

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External links

No external links available for Ccnd2.

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*Ccnd2^{tm1a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ccnd2^{tm1b(KOMP)Mbp}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ccnd2^{tm1e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	ES Cell

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