Cacna1b | calcium channel, voltage-dependent, N type, alpha 1B subunit

GeneMGI:88296Synonyms: Cav2.2, Cchn1a, +1 more

Physiological systems

15 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Homeostasis/metabolism Behavior/neurological

13 No significant impact

9 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

2Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



decreased anxiety-related response	1 supporting dataset	Cacna1b^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.73x10^-13
hyperactivity	8 supporting datasets	Cacna1b^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.12x10^-19
increased exploration in new environment	1 supporting dataset	Cacna1b^{tm1b(KOMP)Wtsi}	homozygote	Early adult	6.94x10^-5
decreased grip strength	4 supporting datasets	Cacna1b^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.62x10^-9
abnormal gait	1 supporting dataset	Cacna1b^{tm1b(KOMP)Wtsi}	homozygote	Early adult	6.29x10^-10
decreased fasting circulating glucose level	1 supporting dataset	Cacna1b^{tm1b(KOMP)Wtsi}	homozygote	Early adult	7.45x10^-5
abnormal locomotor behavior	1 supporting dataset	Cacna1b^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.46x10^-5
decreased thigmotaxis	2 supporting datasets	Cacna1b^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.85x10^-10
abnormal behavior	2 supporting datasets	Cacna1b^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.87x10^-9

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cacna1b.

Associated images

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Histopathology

There is no histopathology data found for Cacna1b.

IMPC related publications

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External links

No external links available for Cacna1b.

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*Cacna1b^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Cacna1b^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Cacna1b^{tm1c(KOMP)Wtsi}*	Wild type floxed exon (post-Flp)	‌	mouse

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