Cacna1b | calcium channel, voltage-dependent, N type, alpha 1B subunit
Physiological systems
15 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Homeostasis/metabolism Behavior/neurological
13 No significant impact
9 Not tested
Data collections
Gene metrics:9Significant phenotypes
2Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| decreased anxiety-related response | 1 supporting dataset | Cacna1btm1b(KOMP)Wtsi | homozygote | Early adult | 1.73x10-13 | ||
| hyperactivity | 8 supporting datasets | Cacna1btm1b(KOMP)Wtsi | homozygote | Early adult | 1.12x10-19 | ||
| increased exploration in new environment | 1 supporting dataset | Cacna1btm1b(KOMP)Wtsi | homozygote | Early adult | 6.94x10-5 | ||
| decreased grip strength | 4 supporting datasets | Cacna1btm1b(KOMP)Wtsi | homozygote | Early adult | 2.62x10-9 | ||
| abnormal gait | 1 supporting dataset | Cacna1btm1b(KOMP)Wtsi | homozygote | Early adult | 6.29x10-10 | ||
| decreased fasting circulating glucose level | 1 supporting dataset | Cacna1btm1b(KOMP)Wtsi | homozygote | Early adult | 7.45x10-5 | ||
| abnormal locomotor behavior | 1 supporting dataset | Cacna1btm1b(KOMP)Wtsi | homozygote | Early adult | 1.46x10-5 | ||
| decreased thigmotaxis | 2 supporting datasets | Cacna1btm1b(KOMP)Wtsi | homozygote | Early adult | 1.85x10-10 | ||
| abnormal behavior | 2 supporting datasets | Cacna1btm1b(KOMP)Wtsi | homozygote | Early adult | 4.87x10-9 |
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| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Cacna1b mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Cacna1b.
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| Cacna1btm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Cacna1btm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Cacna1btm1c(KOMP)Wtsi | Wild type floxed exon (post-Flp) | | mouse |