Cacna2d1 | calcium channel, voltage-dependent, alpha2/delta subunit 1

GeneMGI:88295Synonyms: Cchl2a, Ca(v)alpha2delta1, +1 more

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Nervous system Hematopoietic system Behavior/neurological Skeleton

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal freezing behavior	1 supporting dataset	Cacna2d1^em1(IMPC)Mbp	homozygote	Early adult	2.04x10^-7
increased freezing behavior	2 supporting datasets	Cacna2d1^em1(IMPC)Mbp	homozygote	Early adult	3.6x10^-42
small spleen	1 supporting dataset	Cacna2d1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
increased monocyte cell number	1 supporting dataset	Cacna2d1^em1(IMPC)Mbp	homozygote	Early adult	1.12x10^-5
decreased prepulse inhibition	2 supporting datasets	Cacna2d1^em1(IMPC)Mbp	homozygote	Early adult	6.51x10^-12
abnormal spleen morphology	1 supporting dataset	Cacna2d1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
decreased startle reflex	1 supporting dataset	Cacna2d1^em1(IMPC)Mbp	homozygote	Early adult	1.4x10^-8
enhanced contextual conditioning behavior	1 supporting dataset	Cacna2d1^em1(IMPC)Mbp	homozygote	Early adult	8.56x10^-6
increased circulating alkaline phosphatase level	1 supporting dataset	Cacna2d1^em1(IMPC)Mbp	homozygote	Early adult	2.79x10^-5
impaired glucose tolerance	2 supporting datasets	Cacna2d1^em1(IMPC)Mbp	homozygote	Early adult	1.27x10^-61

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cacna2d1.

Associated images

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Histopathology

There is no histopathology data found for Cacna2d1.

IMPC related publications

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External links

No external links available for Cacna2d1.

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*Cacna2d1^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Cacna2d1^{tm197592(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Cacna2d1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Cacna2d1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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