Cacna1s | calcium channel, voltage-dependent, L type, alpha 1S subunit

GeneMGI:88294Synonyms: Cchl1a3, sj, +5 more

Physiological systems

21 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Respiratory system Behavior/neurological Mortality/aging Cardiovascular system Craniofacial

13 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

8Associated diseases

Expression examined in:48Adult tissues

46Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal placenta vasculature	1 supporting dataset	Cacna1s^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
edema	1 supporting dataset	Cacna1s^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
cyanosis	1 supporting dataset	Cacna1s^{tm1.1(KOMP)Vlcg}	homozygote	E18.5	N/A ^*
unresponsive to tactile stimuli	1 supporting dataset	Cacna1s^{tm1.1(KOMP)Vlcg}	homozygote	E18.5	N/A ^*
hemorrhage	1 supporting dataset	Cacna1s^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
hemorrhage	1 supporting dataset	Cacna1s^{tm1.1(KOMP)Vlcg}	homozygote	E18.5	N/A ^*
decreased circulating glucose level	1 supporting dataset	Cacna1s^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	3.96x10^-5
abnormal embryo size	1 supporting dataset	Cacna1s^{tm1.1(KOMP)Vlcg}	homozygote	E18.5	N/A ^*
abnormal facial morphology	1 supporting dataset	Cacna1s^{tm1.1(KOMP)Vlcg}	homozygote	E18.5	N/A ^*
respiratory system phenotype	1 supporting dataset	Cacna1s^{tm1.1(KOMP)Vlcg}	homozygote	E18.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cacna1s.

Associated images

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Histopathology

There is no histopathology data found for Cacna1s.

IMPC related publications

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External links

No external links available for Cacna1s.

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*Cacna1s^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Cacna1s^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Cacna1s^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Cacna1s^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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