Camk2b | calcium/calmodulin-dependent protein kinase II, beta

GeneMGI:88257Synonyms: CaMK II

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Nervous system Behavior/neurological Mortality/aging

16 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased prepulse inhibition	4 supporting datasets	Camk2b^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	9.25x10^-9
preweaning lethality, incomplete penetrance	1 supporting dataset	Camk2b^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased thigmotaxis	2 supporting datasets	Camk2b^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	8.38x10^-5
hyperactivity	2 supporting datasets	Camk2b^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.69x10^-6
decreased vertical activity	1 supporting dataset	Camk2b^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	4.2x10^-5
improved glucose tolerance	1 supporting dataset	Camk2b^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	4.91x10^-6
abnormal behavior	1 supporting dataset	Camk2b^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	8.38x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Camk2b.

Associated images

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Histopathology

There is no histopathology data found for Camk2b.

IMPC related publications

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External links

No external links available for Camk2b.

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*Camk2b^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Camk2b^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Camk2b^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Camk2b^{tm40351(L1L2_gt2)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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