Btk | Bruton agammaglobulinemia tyrosine kinase

GeneMGI:88216Synonyms: Bruton's tyrosine kinase, X-linked immune deficiency, +1 more

Physiological systems

20 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Immune system Hematopoietic system

18 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased CD4-positive, alpha-beta T cell number	1 supporting dataset	Btk^{tm1a(EUCOMM)Hmgu}	hemizygote	Early adult	5.04x10^-9
decreased erythrocyte cell number	1 supporting dataset	Btk^{tm1a(EUCOMM)Hmgu}	hemizygote	Early adult	3.68x10^-5
increased CD8-positive, alpha-beta T cell number	1 supporting dataset	Btk^{tm1a(EUCOMM)Hmgu}	hemizygote	Early adult	2.48x10^-6
decreased mature B cell number	1 supporting dataset	Btk^{tm1a(EUCOMM)Hmgu}	hemizygote	Early adult	3.91x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Btk.

Associated images

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Histopathology

There is no histopathology data found for Btk.

IMPC related publications

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External links

No external links available for Btk.

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*Btk^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse

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