Bmp6 | bone morphogenetic protein 6

GeneMGI:88182Synonyms: D13Wsu115e, Vgr1

Physiological systems

22 / 24 physiological systems tested

11 Significantly impacted by the knock-out

 Homeostasis/metabolism Endocrine/exocrine gland Integument Growth/size/body region Limbs/digits/tail Nervous system Digestive/alimentary Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

11 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:20Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased mean corpuscular hemoglobin1 supporting datasetBmp6em1(IMPC)CcpczhomozygoteEarly adult1.12x10-12 
abnormal pancreas morphology2 supporting datasetsBmp6em1(IMPC)CcpczhomozygoteEarly adultN/A * 
increased circulating alanine transaminase level1 supporting datasetBmp6em1(IMPC)CcpczhomozygoteEarly adult4.86x10-21 
increased circulating iron level1 supporting datasetBmp6em1(IMPC)CcpczhomozygoteEarly adult4.53x10-109 
decreased heart rate1 supporting datasetBmp6em1(IMPC)CcpczhomozygoteEarly adult4.06x10-5 
increased anxiety-related response1 supporting datasetBmp6em1(IMPC)CcpczhomozygoteEarly adult1.67x10-5 
decreased startle reflex1 supporting datasetBmp6em1(IMPC)CcpczhomozygoteEarly adult1.6x10-5 
increased circulating aspartate transaminase level1 supporting datasetBmp6em1(IMPC)CcpczhomozygoteEarly adult2.54x10-5 
increased brain size1 supporting datasetBmp6em1(IMPC)CcpczhomozygoteEarly adultN/A * 
kyphosis1 supporting datasetBmp6em1(IMPC)CcpczhomozygoteEarly adult3.11x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Bmp6em1(IMPC)CcpczExon Deletionmouse
Bmp6tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell

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