Bmi1 | Bmi1 polycomb ring finger oncogene
Physiological systems
19 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Vision/eye Mortality/aging
14 No significant impact
5 Not tested
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
51Embryo tissues
| abnormal embryo size | 1 supporting dataset | Bmi1tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Bmi1tm1.1(KOMP)Vlcg | heterozygote | E15.5 | N/A * | ||
| edema | 1 supporting dataset | Bmi1tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * | ||
| preweaning lethality, incomplete penetrance | 2 supporting datasets | Bmi1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| edema | 1 supporting dataset | Bmi1tm1.1(KOMP)Vlcg | heterozygote | E15.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Bmi1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| anophthalmia | 1 supporting dataset | Bmi1tm1.1(KOMP)Vlcg | heterozygote | E15.5 | N/A * | ||
| microphthalmia | 1 supporting dataset | Bmi1tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * |
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| adrenal gland | heterozygote | Section images | 50% (1/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 50% (1/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | Section images | 100% (2/2) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
External links
No external links available for Bmi1.
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| Bmi1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Bmi1tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Bmi1tm297191(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |