Bmi1 | Bmi1 polycomb ring finger oncogene

GeneMGI:88174Synonyms: Bmi1, Pcgf4, +1 more

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Embryo Growth/size/body region Vision/eye Mortality/aging

14 No significant impact

5 Not tested

Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
51Embryo tissues

Phenotypes

abnormal embryo size1 supporting datasetBmi1tm1.1(KOMP)VlcghomozygoteE15.5N/A * 
abnormal embryo size1 supporting datasetBmi1tm1.1(KOMP)VlcgheterozygoteE15.5N/A * 
edema1 supporting datasetBmi1tm1.1(KOMP)VlcghomozygoteE15.5N/A * 
preweaning lethality, incomplete penetrance2 supporting datasetsBmi1tm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
edema1 supporting datasetBmi1tm1.1(KOMP)VlcgheterozygoteE15.5N/A * 
preweaning lethality, complete penetrance1 supporting datasetBmi1tm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
anophthalmia1 supporting datasetBmi1tm1.1(KOMP)VlcgheterozygoteE15.5N/A * 
microphthalmia1 supporting datasetBmi1tm1.1(KOMP)VlcghomozygoteE15.5N/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Bmi1tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Bmi1tm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse
Bmi1tm297191(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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