B2m | beta-2 microglobulin
Physiological systems
19 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Integument Nervous system Mortality/aging
14 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
4Associated diseases
Expression examined in:73Adult tissues
29Embryo tissues
| small superior vagus ganglion | 1 supporting dataset | B2mtm1b(EUCOMM)Wtsi | heterozygote | Early adult | N/A * | ||
| hydrometra | 1 supporting dataset | B2mtm1b(EUCOMM)Wtsi | heterozygote | Early adult | N/A * | ||
| preweaning lethality, incomplete penetrance | 2 supporting datasets | B2mtm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | B2mtm1b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * | ||
| increased circulating phosphate level | 1 supporting dataset | B2mtm1b(EUCOMM)Wtsi | heterozygote | Early adult | 8.58x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | B2mtm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal skin morphology | 1 supporting dataset | B2mtm1b(EUCOMM)Wtsi | heterozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 50% (1/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/1) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
External links
No external links available for B2m.
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| B2mtm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| B2mtm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| B2mtm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| B2mtm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |