B2m | beta-2 microglobulin

GeneMGI:88127Synonyms: beta2-m, Ly-m11, +1 more

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Integument Nervous system Mortality/aging

14 No significant impact

5 Not tested

Gene metrics:7Significant phenotypes
4Associated diseases
Expression examined in:73Adult tissues
29Embryo tissues

Phenotypes

small superior vagus ganglion1 supporting datasetB2mtm1b(EUCOMM)WtsiheterozygoteEarly adultN/A * 
hydrometra1 supporting datasetB2mtm1b(EUCOMM)WtsiheterozygoteEarly adultN/A * 
preweaning lethality, incomplete penetrance2 supporting datasetsB2mtm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
embryonic lethality prior to tooth bud stage1 supporting datasetB2mtm1b(EUCOMM)WtsihomozygoteE12.5N/A * 
increased circulating phosphate level1 supporting datasetB2mtm1b(EUCOMM)WtsiheterozygoteEarly adult8.58x10-5 
preweaning lethality, complete penetrance1 supporting datasetB2mtm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
abnormal skin morphology1 supporting datasetB2mtm1b(EUCOMM)WtsiheterozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a0% (0/2)0.7% (4/570)
aortaheterozygoten/a0% (0/2)0.19% (1/533)
bloodheterozygoten/a0% (0/2)0% (0/17)
bone marrowheterozygoten/a0% (0/2)0% (0/22)
brainheterozygoten/a50% (1/2)0.86% (5/579)
brainstemheterozygoten/an/a0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoten/an/a0.22% (1/454)
cecumheterozygoten/a0% (0/1)7.75% (22/284)
cerebellumheterozygoten/a0% (0/2)0.56% (3/532)
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Human diseases caused by B2m mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.






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Histopathology

IMPC related publications

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B2mtm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
B2mtm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
B2mtm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
B2mtm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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