B2m | beta-2 microglobulin
Physiological systems
19 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Integument Nervous system Mortality/aging
14 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
4Associated diseases
Expression examined in:73Adult tissues
29Embryo tissues
| small superior vagus ganglion | 1 supporting dataset | B2mtm1b(EUCOMM)Wtsi | heterozygote | Early adult | N/A * | ||
| hydrometra | 1 supporting dataset | B2mtm1b(EUCOMM)Wtsi | heterozygote | Early adult | N/A * | ||
| preweaning lethality, incomplete penetrance | 2 supporting datasets | B2mtm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | B2mtm1b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * | ||
| increased circulating phosphate level | 1 supporting dataset | B2mtm1b(EUCOMM)Wtsi | heterozygote | Early adult | 8.58x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | B2mtm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal skin morphology | 1 supporting dataset | B2mtm1b(EUCOMM)Wtsi | heterozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 50% (1/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/1) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
Human diseases caused by B2m mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for B2m.
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| B2mtm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| B2mtm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| B2mtm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| B2mtm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |